Our Pluripotency:
You know that feeling "there's something else I'm supposed to be doing"?
It's what catalyzed giving up my cushy career in biomedical cellular research. That venture for deeper discovery led to flipping furniture in a basement and bumbling through production management at a creft brewery before finding answers in master's studies of psychology, early childhood trauma, behavioral science, and reluctant personal studies of spiritual matters.
This guts led re-education culminated in an accidentally successful podcast and support community for CPTSD recoverers and consciousness explorers. The pandemic-spawned project helped thousands to feel less alone, individually doomed, and personally baffling. Equipped with new information and views that challenge the illusions of social programming, we found growth and Self-led healing was possible even for those who had considered themselves too old for new tricks or too damaged to keep trying.
Pluripotent is the next culmination of this work. A more conscious, intentional, organized, and permanent presentation of perspectives that change brains and align lives.
Pluripotent You
Your life and your cellular biology can be seen as parallel life experiences.
Each of us begin but a sphere of stemcells, and those stemcells begin with totipotency. Total-potential. Meaning, their fate is completely undetermined; they have the potential to become anything in the biological system. This fetal phase is fleeting, as totipotent cells form the bases of your entire being and rapidly lose their absolute potential.
Over time, with each generation, cells mature through differentiation and you develop into a functionally animated meat husk thanks to these interconnected adaptations. Each unit responds to cues from their environment, up or down regulate their gene expression, and pass on these instructions during the next replication cycle. Their activites are more targeted as life unfolds. They find their niche.
That specialization comes at a cost.
With each adapation, each furthered step of differentiation, the potential form and function of the cell decreases. The individual's fate is sealed as it becomes locked in forever-relationships and perpetual-duties in its environment. The opportunity cost of becoming specialized to promote system survival is all the other things a cell could have become. It will continue filling this singlular role until the day the individual or entire system is out of resources, too mutated to function properly, or exhausted to destruction.
... But what if the story didn't have to end there?
What if, despite the prior adaptations, each individual's fate was still undetermined?
None of us will ever return to totipotency after the blastosphering stage.
But fret not, Fucker; though our totipotent cells disappear quickly, we still carry flexibly adaptive cells. As we do, let's hear from some experts.
"During the development of multicellular organisms, cells evolve from the initial undifferentiated, totipotent state of the fertilized egg and early embryo to sequentially restricted states while gradually losing their differentiation potential. The capability of generating more committed progenitors is referred to as the degree of “potency” that defines the “stem” status of a cell. Adult organisms are composed of a large panel of differentiated cell types that accomplish various functions within the body. Among them, a variable amount of tissue-resident stem cells have been documented in various human tissues, accounting for tissue turnover and repair after injury. Tissue specific adult stem cells [such as mesenchymal stem cells (MSCs), neural stem cells, and haematopoietic stem cells] exist in dormant states in adult tissues and are thought to be lineage-restricted, meaning they only give rise to progeny of their tissue of origin. Differentiation implies epigenetic silencing of the so-called pluripotency genes and transcriptional activation of protein-coding genes with cell-type specific functions.
The ultimate differentiated state associated with loss of cell division, which is known as terminal differentiation, was long considered irreversible. Seminal Nobel-winning research has gradually deconstructed this dogma. Envisaged by Nobel Prize-winner Hans Spemann in 1935, “the fantastical experiment”[1] was performed several decades later. Using the previously established nuclear transfer technology[2], somatic cell nuclei transferred to an enucleated egg cytoplasm were shown to generate a viable adult organism.
The experiment confirmed that somatic, fully differentiated adult cells not only retain an intact full genome but can also revert to pluripotent stages under permissive conditions[3]."
Labusca L, Mashayekhi K. Human adult pluripotency: Facts and questions. World J Stem Cells. 2019 Jan 26;11(1):1-12.
Pluripotency:
The capacity for fully differentiated adult cells to reverse their programming, skirting terminal differentiation and becoming broadly repotentialized under the right conditions.
Providing those conditions and promoting personal revolution regardless of social status is the Pluripotent Mission.
Problem
Getting trapped in limiting modes of inauthentic living which become permanent structures in our brains and lives, forever containing us in individual work camps where we toil to stave off the perceived threats of life and emotions until the day our systems run dry of fuel and we perish unfulfilled, dissatisfied, and strangers to ourSelves.
Solution
Re-education and reaching higher perspectives to operate from a plane unmarred by the rigid mental patterns, behavioral programs, and cult.ural beliefs that become lifelong prisons.
Credentials
Don't blindly accept, check the sources.
Material
sources and models
Informed by: peer-reviewed research and articles, academic courses and texts, community aggregated information, and 'the spiritual shit.' All sources are referenced within content; full documents cannot be legally shared. Incorporating: Evolutionary Biology, Neuroscience, Systems Biology, Cognitive Psychology, Behavioral Science, Social Psychology, Trauma Psychology, Childhood Development, Internal Family Systems, Nonviolent Communication, DBT, Somatic Experiencing, Buddhism, New Woo, and on.
Perspective
Information foundations, biases, Boundaries
Bounds: Jess B runs this operation. She's older than you think and enjoys peaceful privacy. Email hypervigilance and accepting projections of saviordom are phases of her past. Marcus Barkus is not.
Foundations: B.S. Pre-Medical Animal Science, Chemistry Minor; Peer-reviewed published scientist; Former laboratory supervisor & research advisor;
M.S. Psychology, Behavioral Science; Facilitator undergrad/grad Cognitive Psychology, Creator of Traumatized Motherfuckers CPTSD research podcast and community; Academic expert of parent-child relationships; Begrudging channeler of some spiritual shit; Student of "Self."
Biases: Anti modern religion, government, traditionalism, 'normal' societal programming and social culture.